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NPLOC4 and RAF1
Number of citations of the paper that reports this interaction (PMID
16364241
)
3
Data Source:
BioGRID
(two hybrid)
NPLOC4
RAF1
Gene Name
nuclear protein localization 4 homolog (S. cerevisiae)
Raf-1 proto-oncogene, serine/threonine kinase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum
Cytosol
Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Pseudopodium
Molecular Function
Protein Binding
Zinc Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Identical Protein Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Golgi Organization
ER-associated Ubiquitin-dependent Protein Catabolic Process
Membrane Fusion
MAPK Cascade
Activation Of MAPKK Activity
Response To Hypoxia
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Synaptic Transmission
Axon Guidance
Heart Development
Blood Coagulation
Cell Proliferation
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Platelet Activation
Negative Regulation Of Protein Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Somatic Stem Cell Maintenance
Regulation Of Rho Protein Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Transport
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Motility
Pathways
Signaling by GPCR
Signaling by FGFR in disease
MEK activation
FCERI mediated MAPK activation
CREB phosphorylation through the activation of Ras
Signaling by EGFRvIII in Cancer
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Rap1 signalling
Gastrin-CREB signalling pathway via PKC and MAPK
SOS-mediated signalling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
GP1b-IX-V activation signalling
Signaling by VEGF
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Transmission across Chemical Synapses
Adaptive Immune System
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
Axon guidance
IRS-mediated signalling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
Ion channel transport
GRB2 events in ERBB2 signaling
VEGFR2 mediated cell proliferation
Activation of NMDA receptor upon glutamate binding and postsynaptic events
RAF phosphorylates MEK
Downstream signaling of activated FGFR
Stimuli-sensing channels
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Post NMDA receptor activation events
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
SHC-related events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
ARMS-mediated activation
RAF activation
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs
Sorafenib
Regorafenib
Dabrafenib
Diseases
GWAS
Eye color traits (
20463881
)
Cardiac hypertrophy (
21348951
)
Cholesterol, total (
20686565
)
Protein-Protein Interactions
6 interactors:
GZMK
NEDD8
RAF1
UBC
UFD1L
VCP
123 interactors:
ADCY6
AGTR1
AKT1
AR
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BIRC2
BIRC3
BRAF
CCT3
CDC25A
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
ERBB2IP
FYCO1
FYN
GNB2
GNG4
GRB10
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KRAS
KRT18
KRT8
KSR1
KSR2
LCK
LRPAP1
MAP2K1
MAP2K2
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MRAS
MYBPC1
MYC
NEDD4
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRB
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TIMM50
TMEM70
TSC22D3
UBC
UBE2D2
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
Entrez ID
55666
5894
HPRD ID
06975
01265
Ensembl ID
ENSG00000182446
ENSG00000132155
Uniprot IDs
Q8TAT6
B4E0X2
L7RRS6
P04049
PDB IDs
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
Protein Metabolic Process
Death-inducing Signaling Complex Assembly
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Regulation Of Proteolysis
Catabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Response To Fibroblast Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Metabolic Process
Regulation Of Cysteine-type Endopeptidase Activity
Neurotrophin TRK Receptor Signaling Pathway
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Catabolic Process
Apoptotic Process
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
MAPK Cascade
Programmed Cell Death
Regulation Of Protein Deubiquitination
Protein Processing
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Death
Death
Response To Organic Substance
Protein Hexamerization
Response To Abiotic Stimulus
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Phosphorylation
Signal Transduction
Regulation Of Phosphorus Metabolic Process
Cell Communication
Signaling
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Response To Growth Factor
Response To Fibroblast Growth Factor
Cellular Response To Organic Substance
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Regulation Of MAPK Cascade
Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Programmed Cell Death
Neurotrophin Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Apoptotic Process
Positive Regulation Of Phosphorylation
Cell Death
Death
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Apoptotic Process
Regulation Of Cell Death
Positive Regulation Of Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Innate Immune Response
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Transferase Activity
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pak2
pakl
phenomena
probed
proliferate
proto
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Difference)
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pak2
pakl
phenomena
probed
proliferate
proto
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Intersection)
?