NPLOC4

Description		NPL4 homolog, ubiquitin recognition factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding ATPase Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Translesion Synthesis by POLH Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 28957414 32888494 27863252) Refractive astigmatism ( 30306274) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 TMUB1 UBC UFD1 VPS26B
Entrez ID		55666
HPRD ID		06975
Ensembl ID		ENSG00000182446
Uniprot IDs		Q8TAT6
PDB IDs		7WWP 7WWQ
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Protein Metabolic Process MAP Kinase Kinase Kinase Activity MAPK Cascade Intracellular Protein Localization Intracellular Signaling Cassette GBD Domain Binding Storage Vacuole Phagocytic Vesicle Cellular Response To Type II Interferon Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Death-inducing Signaling Complex Assembly ERAD Pathway UFD1-NPL4 Complex Response To Type II Interferon
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