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PFKFB2 and PRKAA2
Number of citations of the paper that reports this interaction (PMID
12853467
)
22
Data Source:
HPRD
(in vitro)
PFKFB2
PRKAA2
Gene Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
protein kinase, AMP-activated, alpha 2 catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleoplasm
Cytosol
Molecular Function
6-phosphofructo-2-kinase Activity
Fructose-2,6-bisphosphate 2-phosphatase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Biological Process
Carbohydrate Metabolic Process
Fructose Metabolic Process
Fructose 2,6-bisphosphate Metabolic Process
Glucose Metabolic Process
Glucose Catabolic Process
Lactate Metabolic Process
Glycolytic Process
Pathogenesis
Response To Glucose
Dephosphorylation
Positive Regulation Of Insulin Secretion
Positive Regulation Of Glucokinase Activity
Small Molecule Metabolic Process
Carbohydrate Phosphorylation
Energy Reserve Metabolic Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Autophagy
Response To Stress
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Histone-serine Phosphorylation
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Membrane Organization
Regulation Of Energy Homeostasis
Pathways
Glucose metabolism
Myoclonic epilepsy of Lafora
Glycogen storage diseases
Glycolysis
Metabolism of carbohydrates
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Diseases
GWAS
Lymphocyte counts (
22286170
)
Protein-Protein Interactions
9 interactors:
AKT1
GCK
PRKAA1
PRKAA2
PRKACA
PRKCA
YWHAG
YWHAQ
YWHAZ
48 interactors:
ABI2
ACACA
ACACB
AES
AIMP2
APPBP2
C19orf47
CCNB1IP1
EEF2K
EPM2A
FOS
GLI1
HMBOX1
HNF4A
HOMEZ
KCTD1
KIF24
KIFC3
KRT31
KRTAP10-3
L3MBTL3
LEP
MYOZ1
NECAB2
NONO
NOTCH2NL
NRAP
NUTM1
PBXIP1
PFKFB2
PRKAB1
PRKAB2
PRKAG1
RBPMS
RFX6
RPTOR
SNW1
STK11
TCF4
TMOD1
TRIP6
TSC22D4
UBE2I
USHBP1
VPS52
WWP1
ZBTB8A
ZNF397
Entrez ID
5208
5563
HPRD ID
01383
02735
Ensembl ID
ENSG00000123836
ENSG00000162409
Uniprot IDs
B4DY91
O60825
P54646
PDB IDs
2H6D
2LTU
2YZA
3AQV
Enriched GO Terms of Interacting Partners
?
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Glucose Transport
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Peptidyl-serine Phosphorylation
Cellular Response To Peptide Hormone Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cellular Response To Peptide
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Signal Transduction
Energy Reserve Metabolic Process
Apoptotic Signaling Pathway
Histone Phosphorylation
Regulation Of Protein Localization
Regulation Of Apoptotic Process
Membrane Organization
Regulation Of Cell Death
Response To Peptide Hormone
Positive Regulation Of Mitochondrion Organization
Regulation Of Signal Transduction
Cellular Response To Organonitrogen Compound
Glucose Homeostasis
Response To Peptide
Cellular Response To Insulin Stimulus
Regulation Of Glucose Import
Negative Regulation Of Glucose Import
Positive Regulation Of Glycolytic Process
Regulation Of Cellular Localization
Regulation Of Generation Of Precursor Metabolites And Energy
Positive Regulation Of Intracellular Transport
Regulation Of Signaling
Cellular Response To Hormone Stimulus
Regulation Of Mitochondrion Organization
Negative Regulation Of Glucose Transport
Response To Insulin
Energy Derivation By Oxidation Of Organic Compounds
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Transport
Regulation Of Protein Kinase Activity
Cellular Response To Glucose Starvation
Regulation Of Glycolytic Process
Regulation Of Kinase Activity
Positive Regulation Of Dense Core Granule Biogenesis
Response To Organonitrogen Compound
Negative Regulation Of Transport
Glucose Metabolic Process
Chemical Homeostasis
Generation Of Precursor Metabolites And Energy
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Carbohydrate Metabolic Process
Energy Reserve Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Transcription, DNA-templated
Cell Cycle Arrest
Negative Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Carnitine Shuttle
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Regulation Of Nucleic Acid-templated Transcription
Response To Insulin
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Carnitine Transmembrane Transport
Energy Derivation By Oxidation Of Organic Compounds
Macromolecule Biosynthetic Process
Carnitine Transport
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Gene Expression
Cellular Response To Insulin Stimulus
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Malonyl-CoA Biosynthetic Process
Fatty Acid Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Quaternary Ammonium Group Transport
Regulation Of Carbohydrate Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Lipid Metabolic Process
Response To Peptide Hormone
Heterocycle Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Fatty Acid Metabolic Process
Response To Peptide
Cellular Response To Peptide
Regulation Of Insulin Secretion
Glucose Homeostasis
Response To Hormone
Cellular Nitrogen Compound Metabolic Process
Tagcloud
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Difference)
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Intersection)
?