SMPD4 and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMPD4	EXOSC4
Description		sphingomyelin phosphodiesterase 4	exosome component 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Sarcolemma	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Lipid Metabolic Process Sphingomyelin Catabolic Process Endoplasmic Reticulum Organization Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Glycosphingolipid catabolism	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs		Phosphatidyl serine
Diseases
GWAS			Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		2 interacting genes: ERBB2 EXOSC4	34 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PRRC2B PTEN SDCBP SKIC2 SMPD4 TSEN15 UPF1 UPF2 UPF3B WTAP
Entrez ID		55627	54512
HPRD ID		13374	16221
Ensembl ID		ENSG00000136699	ENSG00000178896
Uniprot IDs		A0A7P0TB24 Q9NXE4	Q9NPD3
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Heart Development Negative Regulation Of T Cell Differentiation In Thymus Neuron Differentiation Regulation Of Cell Growth Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Semaphorin Receptor Complex ERBB3:ERBB2 Complex Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Growth ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Protein Heterodimerization Activity ERBB4 Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process General Adaptation Syndrome Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Activin Receptor Binding Nodal Binding Nodal Signaling Pathway Histone MRNA Catabolic Process Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nuclear Retinoid X Receptor Binding Catecholamine Biosynthetic Process RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Maturation Of 5.8S RRNA Regulation Of Dopamine Metabolic Process Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Catabolic Process Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nuclear RNA Surveillance Nuclear MRNA Surveillance RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing MRNA Metabolic Process RRNA 3'-end Processing TRNA Decay SnRNA Metabolic Process RNA Metabolic Process Macromolecule Catabolic Process SnRNA 3'-end Processing RRNA Processing 3'-5'-RNA Exonuclease Activity RRNA Metabolic Process SnRNA Processing RNA Binding Nucleic Acid Metabolic Process CUT Catabolic Process RRNA Catabolic Process RNA 3'-end Processing Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Macromolecule Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolus Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Sno(s)RNA Metabolic Process TRNA Metabolic Process Exoribonuclease Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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