SMPD4 and EXOSC4

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMPD4	EXOSC4
Gene Name		sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	exosome component 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Integral Component Of Membrane	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: EXOSC4	27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		55627	54512
HPRD ID		13374	16221
Ensembl ID		ENSG00000136699	ENSG00000178896
Uniprot IDs		B1PBA3 B4DM23 B4DQ31 B4DWK7 B4E0L6 H7BXF4 Q9NXE4	Q9NPD3
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance RNA Surveillance DNA Deamination Histone MRNA Catabolic Process Maturation Of 5.8S RRNA Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay DNA Modification RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Growth RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Defense Response To Virus RNA Catabolic Process Ribosome Biogenesis Positive Regulation Of Growth Response To Virus Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Aromatic Compound Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process Regulation Of Growth	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process
Tagcloud ?		atrophy c2c12 connection cytosol detergent differently doublet exon fractionates innovation isoform kd links muscles myotube myotubes nsmase nsmase3 nsmase3a nsmase3b oxidant partition readily resides sarcolemmal skeletal sphingolipid sphingomyelinase striated
Tagcloud (Difference) ?		atrophy c2c12 connection cytosol detergent differently doublet exon fractionates innovation isoform kd links muscles myotube myotubes nsmase nsmase3 nsmase3a nsmase3b oxidant partition readily resides sarcolemmal skeletal sphingolipid sphingomyelinase striated
Tagcloud (Intersection) ?