NCBP3 and KPNA4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NCBP3	KPNA4
Name		nuclear cap binding subunit 3	karyopherin subunit alpha 4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Cap Binding Complex Nuclear Speck RNA Cap Binding Complex	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	7-methylguanosine MRNA Capping MRNA Processing MRNA Export From Nucleus SnRNA Export From Nucleus Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II MRNA Transport Defense Response To Virus	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways		None	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
GWAS		Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 )	Alanine aminotransferase levels ( 33547301 ) Alcohol use disorder (total score) ( 30336701 ) Aspartate aminotransferase levels ( 33547301 ) Attention deficit hyperactivity disorder ( 32279069 ) Bipolar disorder ( 31043756 ) Malaria ( 31844061 ) Myeloproliferative neoplasms ( 33057200 ) Pit-and-Fissure caries ( 24556642 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Smooth-surface caries ( 24556642 ) Total cholesterol levels ( 30275531 )
Interacting Genes		8 interacting genes: APP DAPK1 HMGB2 HNRNPH3 KPNA4 LENG8 LRRK2 SRPK2	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		55421	3840
HPRD ID		17116	04275
Ensembl ID		ENSG00000074356	ENSG00000186432
Uniprot IDs		Q53F19	O00629
PDB IDs		8BY6	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
GO Terms Enriched among Interactors		Golgi-associated Vesicle RAGE Receptor Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Syntaxin-1 Binding Positive Regulation Of Programmed Cell Death Chemoattractant Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Positive Chemotaxis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Programmed Cell Death Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Cellular Response To Oxygen-containing Compound Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Serine Kinase Activity Protein Phosphorylation DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Response To Oxidative Stress Phosphorylation Regulation Of Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Response To Stress Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Defense Response To Gram-negative Bacterium Protein Serine/threonine Kinase Activity Non-sequence-specific DNA Binding, Bending Nucleus Organization Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process