NCBP3 and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 29721183)
101

Data Source:
BioGRID (two hybrid)

		NCBP3	HMGB2
Description		nuclear cap binding subunit 3	high mobility group box 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Cap Binding Complex Nuclear Speck RNA Cap Binding Complex	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	7-methylguanosine MRNA Capping MRNA Processing MRNA Export From Nucleus SnRNA Export From Nucleus Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II MRNA Transport Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis
Pathways			Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		8 interacting genes: APP DAPK1 HMGB2 HNRNPH3 KPNA4 LENG8 LRRK2 SRPK2	54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668
Entrez ID		55421	3148
HPRD ID		17116	01229
Ensembl ID		ENSG00000074356	ENSG00000164104
Uniprot IDs		Q53F19	P26583
PDB IDs		8BY6
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle RAGE Receptor Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Syntaxin-1 Binding Positive Regulation Of Programmed Cell Death Chemoattractant Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Positive Chemotaxis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Programmed Cell Death Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Cellular Response To Oxygen-containing Compound Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Serine Kinase Activity Protein Phosphorylation DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Response To Oxidative Stress Phosphorylation Regulation Of Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Response To Stress Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Defense Response To Gram-negative Bacterium Protein Serine/threonine Kinase Activity Non-sequence-specific DNA Binding, Bending Nucleus Organization Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion	Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process
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