HJURP and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		HJURP	KPNA4
Description		Holliday junction recognition protein	karyopherin subunit alpha 4
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	DNA Binding Protein Binding Histone Binding Identical Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Chromosome Segregation CENP-A Containing Chromatin Assembly Regulation Of Protein-containing Complex Assembly Regulation Of DNA Binding	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Hair greying ( 26926045) Headache ( 29397368) Migraine ( 27322543) Migraine without aura ( 27322543) Total bilirubin levels in HIV-1 infection ( 25884002)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: CDK1 CENPA H4C1 IMMT KPNA4 OIP5 STT3A	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		55355	3840
HPRD ID		10912	04275
Ensembl ID		ENSG00000123485	ENSG00000186432
Uniprot IDs		Q8NCD3	O00629
PDB IDs		3R45	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome CENP-A Containing Chromatin Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Protein Localization To Organelle Chromatin Remodeling Chromatin Organization Protein Localization To Chromatin Chromosome Organization Pronuclear Fusion CENP-A Containing Chromatin Structural Constituent Of Chromatin Cell Division Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Response To Hydrogen Peroxide Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Oligosaccharyl Transferase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Cyclin-dependent Protein Kinase Activity Nucleosome Pericentric Heterochromatin Organization CENP-A Recruiting Complex Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Response To Reactive Oxygen Species Thymidine Biosynthetic Process Chromosome Chromosome, Centromeric Region Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Golgi Disassembly Nuclear DNA Replication Chromosome, Telomeric Region Histone Kinase Activity Dopamine Secretion Mitochondrial Crista Junction Thymidine Metabolic Process MICOS Complex Intracellular Protein Localization Catecholamine Secretion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Oligosaccharyltransferase Complex A NLS-dependent Protein Nuclear Import Complex	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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