HJURP and STT3A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HJURP	STT3A
Gene Name		Holliday junction recognition protein	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm	Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding Histone Binding Identical Protein Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Nucleosome Assembly Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Regulation Of Protein Complex Assembly Regulation Of DNA Binding	Protein N-linked Glycosylation Via Asparagine Co-translational Protein Modification Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Chromosome Maintenance Nucleosome assembly Deposition of new CENPA-containing nucleosomes at the centromere	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Schizophrenia ( 21926974)
Protein-Protein Interactions		3 interactors: HIST1H4A IMMT STT3A	6 interactors: CSDE1 HJURP IRAK2 ITM2C SARM1 TMEM173
Entrez ID		55355	3703
HPRD ID		10912	03086
Ensembl ID		ENSG00000123485	ENSG00000134910
Uniprot IDs		Q8NCD3	B4DJ24 E9PNQ1 P46977
PDB IDs		3R45
Enriched GO Terms of Interacting Partners?		Co-translational Protein Modification Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Mitochondrial Calcium Ion Homeostasis Regulation Of Megakaryocyte Differentiation CENP-A Containing Nucleosome Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Chromatin Silencing DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Protein Demethylation Centromere Complex Assembly Response To Cold DNA Methylation Demethylation ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Homeostatic Process Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Protein N-linked Glycosylation Via Asparagine Gene Silencing	Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Immune Response Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Binding Cellular Response To Exogenous DsRNA Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Regulation Of Neuron Projection Development Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Interleukin-1-mediated Signaling Pathway Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Organization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway CENP-A Containing Nucleosome Assembly Regulation Of Neuron Differentiation Regulation Of Defense Response To Virus By Host
Tagcloud ?		assembly cdk1 cenp centromere centromeres centromeric dephosphorylation deposition dynamic eliminates exit favor identity loading making minimum mitosis mitotic newly orchestrates pp1alpha precise premature preventing propagation ser68 spatiotemporal synthesized variant	acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Difference) ?		assembly cdk1 cenp centromere centromeres centromeric dephosphorylation deposition dynamic eliminates exit favor identity loading making minimum mitosis mitotic newly orchestrates pp1alpha precise premature preventing propagation ser68 spatiotemporal synthesized variant	acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Intersection) ?