HJURP and CENPA

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology)

		HJURP	CENPA
Description		Holliday junction recognition protein	centromere protein A
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleosome Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol CENP-A Containing Nucleosome CENP-A Containing Chromatin
	Molecular Function	DNA Binding Protein Binding Histone Binding Identical Protein Binding	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromosome Segregation CENP-A Containing Chromatin Assembly Regulation Of Protein-containing Complex Assembly Regulation Of DNA Binding	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis CENP-A Containing Chromatin Assembly Cell Division Kinetochore Assembly Protein Localization To CENP-A Containing Chromatin Protein Localization To Chromosome, Centromeric Region
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Hair greying ( 26926045) Headache ( 29397368) Migraine ( 27322543) Migraine without aura ( 27322543) Total bilirubin levels in HIV-1 infection ( 25884002)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: CDK1 CENPA H4C1 IMMT KPNA4 OIP5 STT3A	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		55355	1058
HPRD ID		10912	00313
Ensembl ID		ENSG00000123485	ENSG00000115163
Uniprot IDs		Q8NCD3	P49450
PDB IDs		3R45	3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20 7PII 7R5R 7U46 7U47 7U4D 7YWX 7YYH 9GXA
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome CENP-A Containing Chromatin Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Protein Localization To Organelle Chromatin Remodeling Chromatin Organization Protein Localization To Chromatin Chromosome Organization Pronuclear Fusion CENP-A Containing Chromatin Structural Constituent Of Chromatin Cell Division Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Response To Hydrogen Peroxide Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Oligosaccharyl Transferase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Cyclin-dependent Protein Kinase Activity Nucleosome Pericentric Heterochromatin Organization CENP-A Recruiting Complex Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Response To Reactive Oxygen Species Thymidine Biosynthetic Process Chromosome Chromosome, Centromeric Region Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Golgi Disassembly Nuclear DNA Replication Chromosome, Telomeric Region Histone Kinase Activity Dopamine Secretion Mitochondrial Crista Junction Thymidine Metabolic Process MICOS Complex Intracellular Protein Localization Catecholamine Secretion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Oligosaccharyltransferase Complex A NLS-dependent Protein Nuclear Import Complex	Chromosome Protein Localization To Chromosome NAD+-protein-serine ADP-ribosyltransferase Activity Protein Localization To Organelle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Localization To Chromatin Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Organelle Organization Cellular Response To UV Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Spindle Midzone Assembly NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Remodeling Cellular Response To Light Stimulus Negative Regulation Of CGAS/STING Signaling Pathway Protein Poly-ADP-ribosylation Telomere Organization NAD+-protein Mono-ADP-ribosyltransferase Activity Chromatin Organization Post-translational Protein Modification Decidualization DNA Repair-dependent Chromatin Remodeling DNA Modification Response To UV NAD+ Poly-ADP-ribosyltransferase Activity Chromosome, Centromeric Region Protein Serine/threonine/tyrosine Kinase Activity Spindle Midzone Kinetochore Cellular Response To Radiation Nucleolus Actin Filament Polymerization Nucleosome Binding Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Immune System Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Spindle Microtubule Site Of DNA Damage Positive Regulation Of Cytokinesis Intracellular Protein Localization Nucleus Spindle Positive Regulation Of Cell Cycle Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
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