ANGPTL4 and BRMS1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		ANGPTL4	BRMS1
Description		angiopoietin like 4	BRMS1 transcriptional repressor and anoikis regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Lipase Binding Identical Protein Binding Lipase Inhibitor Activity	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Angiogenesis Response To Hypoxia Lipid Metabolic Process Blood Coagulation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Apoptotic Process Protein Unfolding Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Multicellular Organismal Process Triglyceride Homeostasis Endothelial Cell Apoptotic Process Regulation Of Chylomicron Remodeling Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Regulation of CDH11 function MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 30275531 28270201 25961943 19060906 24507774 24097068) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Phospholipid levels in large HDL ( 29084231) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 30698716 32154731 33339817 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 25961943 27036123 30275531) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1	50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1
Entrez ID		51129	25855
HPRD ID		16173	05879
Ensembl ID		ENSG00000167772	ENSG00000174744
Uniprot IDs		Q9BY76	G5E9I4 Q9HCU9
PDB IDs		6EUB 6U0A 6U1U 6U73	2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Regulation Of Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Process Branch Elongation Of An Epithelium Response To Estradiol Positive Regulation Of Macrophage Differentiation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cell Development Regulation Of Developmental Process Mammary Gland Epithelial Cell Proliferation Apoptotic Process Branching Involved In Mammary Gland Duct Morphogenesis Axis Elongation Developmental Growth Involved In Morphogenesis Regulation Of Hemopoiesis Cell Death Programmed Cell Death Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Protein Kinase Binding Regulation Of Extracellular Matrix Disassembly Lipid Homeostasis Regulation Of Macrophage Differentiation Negative Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MiRNA Transcription Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Liver Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Carbohydrate Homeostasis	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex
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