SUMF2 and ZFYVE9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SUMF2	ZFYVE9
Description		sulfatase modifying factor 2	zinc finger FYVE-type containing 9
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process		Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport
Pathways		The activation of arylsulfatases Glycosphingolipid catabolism
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: CACNA1A FBXW7 ZDHHC17 ZFYVE9	38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		25870	9372
HPRD ID		06400	04782
Ensembl ID		ENSG00000129103	ENSG00000157077
Uniprot IDs		A8MXB9 C9J660 Q8NBJ7	O95405
PDB IDs		1Y4J	1DEV 1MK2 4BKW 5MJY
Enriched GO Terms of Interacting Partners?		Protein-cysteine S-myristoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Ubiquitin Recycling Phosphothreonine Residue Binding Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Osteoclast Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-cysteine S-stearoyltransferase Activity Regulation Of ERK1 And ERK2 Cascade Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Osteoclast Development Regulation Of SREBP Signaling Pathway Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth
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