PPP2R5C and BUB1B

Number of citations of the paper that reports this interaction (PubMedID 23345399)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PPP2R5C	BUB1B
Description		protein phosphatase 2 regulatory subunit B'gamma	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Sister Chromatid Cohesion	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS		Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)	Chronic lymphocytic leukemia ( 24292274 28165464)
Interacting Genes		21 interacting genes: APP ATM AXIN1 BRCA1 BUB1B CHEK2 CIP2A EP300 IER3 MAPK1 MBP OGT PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1	31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13
Entrez ID		5527	701
HPRD ID		03385	04176
Ensembl ID		ENSG00000078304	ENSG00000156970
Uniprot IDs		A0A8Q3WKR3 Q13362	O60566
PDB IDs		2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 7OUF 7OUG 7OUH 7PEL 7SOY	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?		Response To Radiation Regulation Of Carbohydrate Catabolic Process Intracellular Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Regulation Of Small Molecule Metabolic Process Cell Death Regulation Of Generation Of Precursor Metabolites And Energy DNA Damage Response Regulation Of ATP Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Purine Nucleotide Metabolic Process PTW/PP1 Phosphatase Complex Intrinsic Apoptotic Signaling Pathway Regulation Of Organelle Organization Chromosome Cellular Response To Stress Chromosome Organization Protein Modification Process Regulation Of Cellular Response To Stress Regulation Of Cellular Component Organization Cytosol Circadian Rhythm Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Regulation Of Intracellular Transport Regulation Of Cell Cycle Phase Transition Cell Division Signal Transduction In Response To DNA Damage RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Circadian Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Signaling Response To Lead Ion Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Radiation Positive Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Regulation Of Cell Cycle Process Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Localization Organelle Organization Phosphate-containing Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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