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PPP2R5C and SGO1
Number of citations of the paper that reports this interaction (PubMedID
16541024
)
0
Data Source:
HPRD
(in vivo)
PPP2R5C
SGO1
Description
protein phosphatase 2 regulatory subunit B'gamma
shugoshin 1
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Chromosome
Golgi Apparatus
Cytosol
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome, Centromeric Region
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Nuclear Speck
Molecular Function
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Protein Binding
Kinase Binding
Biological Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Meiotic Sister Chromatid Cohesion
Chromosome Segregation
Attachment Of Spindle Microtubules To Kinetochore
Centriole-centriole Cohesion
Meiotic Chromosome Segregation
Cell Division
Mitotic Sister Chromatid Cohesion, Centromeric
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
EML4 and NUDC in mitotic spindle formation
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Anti-saccade response (
29064472
)
Autism (
20663923
)
Leukoderma in response to rhododendrol (
32558222
)
Metabolite levels (
23823483
)
Interacting Genes
21 interacting genes:
APP
ATM
AXIN1
BRCA1
BUB1B
CHEK2
CIP2A
EP300
IER3
MAPK1
MBP
OGT
PAXIP1
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1B
PRKCD
PXN
SGO1
21 interacting genes:
CDCA8
LRRC59
PPP2CA
PPP2CB
PPP2R1A
PPP2R1B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
PRKDC
PTPA
RPL10A
RPL28
RPL7
RPL7A
RPLP1
SET
XRCC5
XRCC6
Entrez ID
5527
151648
HPRD ID
03385
12377
Ensembl ID
ENSG00000078304
ENSG00000129810
Uniprot IDs
A0A8Q3WKR3
Q13362
B5BUA4
Q5FBB7
PDB IDs
2IAE
2JAK
2NPP
2NYL
2NYM
3FGA
5JJA
5K6S
5SW9
5SWF
6OYL
6TOQ
6VOY
6VRO
7OUF
7OUG
7OUH
7PEL
7SOY
3FGA
3Q6S
4A0I
7ZJS
Enriched GO Terms of Interacting Partners
?
Response To Radiation
Regulation Of Carbohydrate Catabolic Process
Intracellular Signal Transduction
Apoptotic Process
Regulation Of Glycolytic Process
Programmed Cell Death
Regulation Of Small Molecule Metabolic Process
Cell Death
Regulation Of Generation Of Precursor Metabolites And Energy
DNA Damage Response
Regulation Of ATP Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Purine Nucleotide Metabolic Process
PTW/PP1 Phosphatase Complex
Intrinsic Apoptotic Signaling Pathway
Regulation Of Organelle Organization
Chromosome
Cellular Response To Stress
Chromosome Organization
Protein Modification Process
Regulation Of Cellular Response To Stress
Regulation Of Cellular Component Organization
Cytosol
Circadian Rhythm
Regulation Of Reactive Oxygen Species Metabolic Process
Signal Transduction
Regulation Of Intracellular Transport
Regulation Of Cell Cycle Phase Transition
Cell Division
Signal Transduction In Response To DNA Damage
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
Circadian Regulation Of Gene Expression
Mitotic DNA Damage Checkpoint Signaling
Response To Lead Ion
Mitotic DNA Integrity Checkpoint Signaling
Cellular Response To Radiation
Positive Regulation Of Metabolic Process
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle
Chromosome, Telomeric Region
Regulation Of Cell Cycle Process
Apoptotic Signaling Pathway
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Cellular Localization
Organelle Organization
Phosphate-containing Compound Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cell Cycle
Protein Dephosphorylation
Protein Serine/threonine Phosphatase Activity
Protein Phosphatase Type 2A Complex
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Meiotic Sister Chromatid Cohesion
Chromosome Organization
Cytosolic Large Ribosomal Subunit
DNA-dependent Protein Kinase Complex
Chromosome, Centromeric Region
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nonhomologous End Joining Complex
Cytosolic Ribosome
Sister Chromatid Cohesion
Cytosol
Cytoplasmic Translation
Nucleus
Structural Constituent Of Ribosome
FAR/SIN/STRIPAK Complex
Chromosome
DNA End Binding
Ku70:Ku80 Complex
Ribosome
Small-subunit Processome Assembly
Cytoplasm
Ribonucleoprotein Complex
Meiotic Sister Chromatid Cohesion, Centromeric
Protein-DNA Complex
5'-deoxyribose-5-phosphate Lyase Activity
Response To Gamma Radiation
Nuclear Telomere Cap Complex
Double-stranded Telomeric DNA Binding
Macromolecule Biosynthetic Process
Spindle Organization
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Ribonucleoprotein Complex Biogenesis
Translation
U3 SnoRNA Binding
Protein Serine/threonine Phosphatase Activity
INTAC Complex
Spindle Assembly
Response To Lead Ion
Telomere Maintenance
RNA Polymerase II Transcription Initiation Surveillance
Negative Regulation Of Hippo Signaling
Ribosome Biogenesis
Hyperosmotic Response
RNA Binding
Maturation Of LSU-rRNA
Telomeric DNA Binding
Cellular Response To Gamma Radiation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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