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PPP2R5C
Gene Name
protein phosphatase 2, regulatory subunit B, gamma
Image
Gene Ontology Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Molecular Function
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Biological Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction
Negative Regulation Of Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Catalytic Activity
Pathways
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Mitotic Anaphase
Signaling by Wnt
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Degradation of beta-catenin by the destruction complex
S37 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
CTLA4 inhibitory signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Cell Cycle, Mitotic
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Autism (
20663923
)
Protein-protein Interactions
14 interactors:
APP
AXIN1
BRCA1
CHEK2
EP300
IER3
MAPK1
MBP
PAXIP1
PPP2CA
PPP2R1B
PRKCD
PXN
SGOL1
Entrez ID
5527
HPRD ID
03385
Ensembl ID
ENSG00000078304
Uniprot IDs
Q13362
PDB IDs
2IAE
2JAK
2NPP
2NYL
2NYM
3FGA
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cellular Ketone Metabolic Process
Cellular Response To Stress
Positive Regulation Of Cellular Protein Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Developmental Process
Positive Regulation Of Metabolic Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Protein Modification Process
Regulation Of Signal Transduction
Regulation Of MAP Kinase Activity
Regulation Of Signaling
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Protein Stability
Apoptotic Signaling Pathway
Cellular Protein Modification Process
Signaling
Regulation Of Protein Kinase Activity
Cell Communication
Regulation Of Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Posttranscriptional Regulation Of Gene Expression
Anatomical Structure Development
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Signal Transduction
Cell Cycle Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Anatomical Structure Morphogenesis
Response To Abiotic Stimulus
Cellular Protein Metabolic Process
Protein Stabilization
Signal Transduction In Response To DNA Damage
Positive Regulation Of Histone H3-K4 Methylation
Tagcloud
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3beta
annexin
ataxia
atm
cck
downregulated
efficient
glycogen
gsk
homolog
interference
jurkat
leukemias
leukemic
mdm2
molt
nonsilencing
nucleofection
pi
qrt
scrambled
sirna
sirna2
sirnas
tcr
telangiectasia
transfected
treat
twofold