F3 and HPCAL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		F3	HPCAL4
Description		coagulation factor III, tissue factor	hippocalcin like 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Serine-type Peptidase Complex
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Cytokine Receptor Activity Protein Binding Phospholipid Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Response To Stress Blood Coagulation Hemostasis Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Endothelial Cell Apoptotic Process	Central Nervous System Development Response To Heat Regulation Of Signal Transduction
Pathways		Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription
Drugs		IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) End-stage coagulation ( 23381943) Smoking status (heavy vs never) ( 26423011) Type 2 diabetes ( 22238593)	Bone mineral density (Ward's triangle area) ( 27397699)
Interacting Genes		8 interacting genes: F10 F7 FANCB FLNA HPCAL4 MDM2 PLG PTPA	16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A
Entrez ID		2152	51440
HPRD ID		00603	17113
Ensembl ID		ENSG00000117525	ENSG00000116983
Uniprot IDs		P13726	B4DGW9 Q9UM19
PDB IDs		1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA 5W06 6R2W 6Z9W 8CN9 8QOD 8QQ6 8UUD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Cell Migration Regulation Of Cell Motility Serine-type Endopeptidase Activity Regulation Of Locomotion Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Protein Domain Specific Binding Regulation Of Body Fluid Levels Protein Maturation Positive Regulation Of Wound Healing Response To Astaxanthin Response To Estrogen Regulation Of Blood Coagulation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Nucleocytoplasmic Transport Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Hemostasis Response To Vitamin Signaling Receptor Binding Endopeptidase Activity Positive Regulation Of TOR Signaling Tissue Remodeling Positive Regulation Of Intracellular Protein Transport Mitotic Spindle Organization Golgi Lumen Serine-type Peptidase Complex Peptidase Activity Response To Thyrotropin-releasing Hormone Kinase Binding Regulation Of Cell Communication Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Regulation Of Signaling Proteolysis Regulation Of Nucleocytoplasmic Transport Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
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