F3 and FANCB

Number of citations of the paper that reports this interaction (PubMedID 9480775)
0

Data Source:
HPRD (in vitro)

		F3	FANCB
Description		coagulation factor III, tissue factor	FA complementation group B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Serine-type Peptidase Complex	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Cytokine Receptor Activity Protein Binding Phospholipid Binding	Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Response To Stress Blood Coagulation Hemostasis Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Endothelial Cell Apoptotic Process	DNA Repair DNA Damage Response Interstrand Cross-link Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription	Fanconi Anemia Pathway PKR-mediated signaling
Drugs		IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin
Diseases			Fanconi anemia
GWAS		Blood protein levels in cardiovascular risk ( 28369058) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) End-stage coagulation ( 23381943) Smoking status (heavy vs never) ( 26423011) Type 2 diabetes ( 22238593)
Interacting Genes		8 interacting genes: F10 F7 FANCB FLNA HPCAL4 MDM2 PLG PTPA	5 interacting genes: CFTR F3 FAAP100 FANCF FANCL
Entrez ID		2152	2187
HPRD ID		00603	06557
Ensembl ID		ENSG00000117525	ENSG00000181544
Uniprot IDs		P13726	A0A8Q3WL66 C9J5X9 Q8NB91
PDB IDs		1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA 5W06 6R2W 6Z9W 8CN9 8QOD 8QQ6 8UUD	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Cell Migration Regulation Of Cell Motility Serine-type Endopeptidase Activity Regulation Of Locomotion Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Protein Domain Specific Binding Regulation Of Body Fluid Levels Protein Maturation Positive Regulation Of Wound Healing Response To Astaxanthin Response To Estrogen Regulation Of Blood Coagulation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Nucleocytoplasmic Transport Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Hemostasis Response To Vitamin Signaling Receptor Binding Endopeptidase Activity Positive Regulation Of TOR Signaling Tissue Remodeling Positive Regulation Of Intracellular Protein Transport Mitotic Spindle Organization Golgi Lumen Serine-type Peptidase Complex Peptidase Activity Response To Thyrotropin-releasing Hormone Kinase Binding Regulation Of Cell Communication Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Regulation Of Signaling Proteolysis Regulation Of Nucleocytoplasmic Transport Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Fanconi Anaemia Nuclear Complex Interstrand Cross-link Repair Response To Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Activation Of Plasma Proteins Involved In Acute Inflammatory Response DNA Repair Cellular Response To Stress Positive Regulation Of Anion Channel Activity Activation Of Blood Coagulation Via Clotting Cascade Serine-type Peptidase Complex Positive Regulation Of Monoatomic Anion Transport DNA Metabolic Process DNA Damage Response Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Chromatin Regulation Of Body Fluid Levels Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Water Transport Bicarbonate Transport Positive Regulation Of Blood Coagulation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Positive Chemotaxis Positive Regulation Of Endothelial Cell Apoptotic Process
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