F3 and F7

Number of citations of the paper that reports this interaction (PubMedID 9925787)
0

Data Source:
HPRD (in vitro)

		F3	F7
Description		coagulation factor III, tissue factor	coagulation factor VII
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Serine-type Peptidase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Vesicle Serine-type Peptidase Complex
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Cytokine Receptor Activity Protein Binding Phospholipid Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Response To Stress Blood Coagulation Hemostasis Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Endothelial Cell Apoptotic Process	Response To Hypoxia Positive Regulation Of Leukocyte Chemotaxis Proteolysis Response To Stress Blood Coagulation Hemostasis Circadian Rhythm Response To Hormone Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of TOR Signaling Response To Estradiol Response To Vitamin K Response To Genistein Response To Estrogen Regulation Of Body Fluid Levels Positive Regulation Of Positive Chemotaxis Response To Growth Hormone Response To Cholesterol Response To Thyroid Hormone Response To Thyroxine Response To Thyroid Stimulating Hormone Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Astaxanthin Response To Thyrotropin-releasing Hormone
Pathways		Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription	BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins
Drugs		IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin	IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) End-stage coagulation ( 23381943) Smoking status (heavy vs never) ( 26423011) Type 2 diabetes ( 22238593)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Prothrombin time ( 22703881 29403010)
Interacting Genes		8 interacting genes: F10 F7 FANCB FLNA HPCAL4 MDM2 PLG PTPA	7 interacting genes: ALB F10 F3 F9 GGCX HPN RCHY1
Entrez ID		2152	2155
HPRD ID		00603	01965
Ensembl ID		ENSG00000117525	ENSG00000057593
Uniprot IDs		P13726	B4DPM2 F5H8B0 P08709
PDB IDs		1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA 5W06 6R2W 6Z9W 8CN9 8QOD 8QQ6 8UUD	1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT6 4YT7 4Z6A 4ZMA 4ZXX 4ZXY 5I46 5L0S 5L2Y 5L2Z 5L30 5PA8 5PA9 5PAA 5PAB 5PAC 5PAE 5PAF 5PAG 5PAI 5PAJ 5PAK 5PAM 5PAN 5PAO 5PAQ 5PAR 5PAS 5PAT 5PAU 5PAV 5PAW 5PAX 5PAY 5PB0 5PB1 5PB2 5PB3 5PB4 5PB5 5PB6 5TQE 5TQF 5TQG 5U6J 8UUD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Cell Migration Regulation Of Cell Motility Serine-type Endopeptidase Activity Regulation Of Locomotion Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Protein Domain Specific Binding Regulation Of Body Fluid Levels Protein Maturation Positive Regulation Of Wound Healing Response To Astaxanthin Response To Estrogen Regulation Of Blood Coagulation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Nucleocytoplasmic Transport Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Hemostasis Response To Vitamin Signaling Receptor Binding Endopeptidase Activity Positive Regulation Of TOR Signaling Tissue Remodeling Positive Regulation Of Intracellular Protein Transport Mitotic Spindle Organization Golgi Lumen Serine-type Peptidase Complex Peptidase Activity Response To Thyrotropin-releasing Hormone Kinase Binding Regulation Of Cell Communication Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Regulation Of Signaling Proteolysis Regulation Of Nucleocytoplasmic Transport Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Coagulation Blood Coagulation Hemostasis Serine-type Endopeptidase Activity Endoplasmic Reticulum Lumen Regulation Of Body Fluid Levels Protein Maturation Serine-type Peptidase Activity Proteolysis Protein Processing Regulation Of Biological Quality Protein Metabolic Process Activation Of Plasma Proteins Involved In Acute Inflammatory Response Gamma-glutamyl Carboxylase Activity Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Activation Of Blood Coagulation Via Clotting Cascade Positive Regulation Of TOR Signaling Serine-type Peptidase Complex Peptidase Activity Golgi Lumen Vitamin Binding Negative Regulation Of Bone Development Phospholipid Binding Negative Regulation Of Testosterone Biosynthetic Process Basement Membrane Disassembly Pilomotor Reflex Extracellular Space Regulation Of TOR Signaling Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Error-free Translesion Synthesis Positive Regulation Of Epithelial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteolysis Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Plasminogen Activation Regulation Of Bone Development Positive Regulation Of Hepatocyte Proliferation Toxic Substance Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Vitamin K Metabolic Process Extracellular Region Regulation Of Hepatocyte Proliferation Regulation Of Plasminogen Activation
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