UBE2O and CPNE1

Number of citations of the paper that reports this interaction (PubMedID 12522145)
0

Data Source:
HPRD (two hybrid, in vitro)

		UBE2O	CPNE1
Description		ubiquitin conjugating enzyme E2 O	copine 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Phosphatidylserine Binding Endopeptidase Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Metal Ion Binding NF-kappaB Binding
	Biological Process	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3	22 interacting genes: ACTB BCOR BUB3 CCDC22 CEBPA CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SNCA SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP
Entrez ID		63893	8904
HPRD ID		10928	05014
Ensembl ID		ENSG00000175931	ENSG00000214078
Uniprot IDs		Q9C0C9	B0QZ18 Q99829
PDB IDs		7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane	Regulation Of Norepinephrine Uptake Cellular Response To Metal Ion Response To Metal Ion Transporter Regulator Activity Tau Protein Binding Regulation Of Protein Localization To Cell Periphery Protein-containing Complex Nucleus Regulation Of Organelle Organization Protein-containing Complex Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apical Protein Localization Cellular Response To Lithium Ion Magnesium Ion Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Response To Lithium Ion MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Structural Constituent Of Cytoskeleton Regulation Of Apoptotic Process Cytoskeleton Regulation Of Programmed Cell Death Nucleoplasm Regulation Of Cellular Component Organization Cortical Cytoskeleton Glutamatergic Synapse Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Receptor Localization To Synapse Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Cell Development Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Establishment Of Integrated Proviral Latency Central Nervous System Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly
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