UBE2O and MAF

Number of citations of the paper that reports this interaction (PubMedID 28673317)
25

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		UBE2O	MAF
Description		ubiquitin conjugating enzyme E2 O	MAF bZIP transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RUNX2 regulates osteoblast differentiation
Drugs
Diseases			Multiple myeloma
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)	Alanine aminotransferase levels ( 34315874 33547301) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Colorectal cancer ( 31826910 30529582) Depressive symptoms (SSRI exposure interaction) ( 25649181) Estimated glomerular filtration rate ( 31015462) Height ( 20668459) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lysophosphatidylcholine levels ( 31551469) Macular thickness ( 30535121) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602 21833088 31604244) Obesity ( 19151714) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Refractive error ( 32231278) Renal function-related traits (urate) ( 22797727) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 29403010 33547301 33339817) Serum thyroid-stimulating hormone levels ( 24852370) Serum uric acid levels ( 30993211) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293) Triglyceride levels ( 32203549) Urate levels ( 31985003 23263486) Vitamin C levels ( 33203707)
Interacting Genes		23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3	16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2
Entrez ID		63893	4094
HPRD ID		10928	01518
Ensembl ID		ENSG00000175931	ENSG00000178573
Uniprot IDs		Q9C0C9	H3BP11 O75444
PDB IDs		7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane	Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels
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