PRR35 and TTLL12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRR35	TTLL12
Description		proline rich 35	tubulin tyrosine ligase like 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Midbody
	Molecular Function	Protein Binding	Nucleotide Binding Tubulin-tyrosine Ligase Activity Protein Binding ATP Binding Histone H4K20me2 Reader Activity Histone H4K20 Trimethyltransferase Activity
	Biological Process		Immune System Process Chromatin Organization Regulation Of Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Molar-incisor hypomineralization ( 23918034) Monocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		80 interacting genes: ABHD11 ACTMAP ACY1 APPL2 ARMC5 ASB15 BEGAIN BIRC7 BPIFA1 CARD10 CCDC136 CFAP68 CNOT2 CRX CYSRT1 EXOC8 FAM168B FHL3 FRYL GIGYF1 GRAP2 HOMER3 HOOK2 HPCA HSPB2 HSPB2-C11orf52 INSC INTS11 JUP KLHL26 KRT31 KRT34 KRT35 KRTAP10-7 KRTAP12-1 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LONRF1 LZTS2 MAGED1 MCCD1 MKRN3 MSS51 MTUS2 N4BP3 NBPF19 NOTCH2NLA OIP5 OXER1 PFDN5 PLAGL2 PPIL1 PPP1R13B PRR20A PRR20B PRR20C PRR20D PRR20E PSTPIP1 RBPMS RNF144B RUSC1 SMUG1 SPAG8 TBX19 TLE5 TRIM27 TRIM54 TRIM73 TTC19 TTLL12 UBASH3B UBXN11 USP54 ZMYND12 ZNF655	10 interacting genes: CEBPA CSNK2A2 DNAJB1 EEF1A1 EEF1A2 FAM222B FILNC1 LCOR PRR35 SUMO2
Entrez ID		146325	23170
HPRD ID		10046	13782
Ensembl ID		ENSG00000161992	ENSG00000100304
Uniprot IDs		P0CG20	Q14166
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Regulation Of Protein Catabolic Process Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Chaperone-mediated Autophagy Cytoplasmic Side Of Lysosomal Membrane Translation Elongation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translational Elongation Positive Regulation Of Lipid Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Regulation Of Autophagy Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Liver Development Protein Kinase CK2 Complex Positive Regulation Of Protein Folding Positive Regulation Of Proteasomal Protein Catabolic Process White Fat Cell Proliferation Regulation Of Lipid Kinase Activity Histone Deacetylase Binding Regeneration Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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