PRR35 and ACY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRR35	ACY1
Description		proline rich 35	aminoacylase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Aminoacylase Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process		Amino Acid Metabolic Process
Pathways			Aflatoxin activation and detoxification Defective ACY1 causes encephalopathy Paracetamol ADME
Drugs			Aspartic acid Acetylcysteine Copper
Diseases
GWAS		L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		80 interacting genes: ABHD11 ACTMAP ACY1 APPL2 ARMC5 ASB15 BEGAIN BIRC7 BPIFA1 CARD10 CCDC136 CFAP68 CNOT2 CRX CYSRT1 EXOC8 FAM168B FHL3 FRYL GIGYF1 GRAP2 HOMER3 HOOK2 HPCA HSPB2 HSPB2-C11orf52 INSC INTS11 JUP KLHL26 KRT31 KRT34 KRT35 KRTAP10-7 KRTAP12-1 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LONRF1 LZTS2 MAGED1 MCCD1 MKRN3 MSS51 MTUS2 N4BP3 NBPF19 NOTCH2NLA OIP5 OXER1 PFDN5 PLAGL2 PPIL1 PPP1R13B PRR20A PRR20B PRR20C PRR20D PRR20E PSTPIP1 RBPMS RNF144B RUSC1 SMUG1 SPAG8 TBX19 TLE5 TRIM27 TRIM54 TRIM73 TTC19 TTLL12 UBASH3B UBXN11 USP54 ZMYND12 ZNF655	11 interacting genes: APP BCAS2 NPM1 NTAQ1 POT1 PRR35 TENT5B TERF1 TLX3 TTC1 WWOX
Entrez ID		146325	95
HPRD ID		10046	00092
Ensembl ID		ENSG00000161992	ENSG00000243989
Uniprot IDs		P0CG20	Q03154 V9HWA0
PDB IDs			1Q7L
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein-N-terminal Glutamine Amidohydrolase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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