RAB18 and TOM1L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RAB18	TOM1L1
Gene Name		RAB18, member RAS oncogene family	target of myb1 (chicken)-like 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Golgi Apparatus Plasma Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Rab Protein Signal Transduction Lipid Particle Organization Endoplasmic Reticulum Tubular Network Organization	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CHM PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1	27 interactors: AMFR CCDC47 CELF1 COPS7A CWF19L1 FAM208A FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TOLLIP TSG101 TUBA1B UBXN4 VAV2 VCP
Entrez ID		22931	10040
HPRD ID		03731	05266
Ensembl ID		ENSG00000099246	ENSG00000141198
Uniprot IDs		B7Z4P9 B7Z5V3 Q9NP72	B7Z9E2 I3L4I4 O75674
PDB IDs		1X3S	3RRU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-serine Dephosphorylation Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Death Death Protein Geranylgeranylation Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Regulation Of Apoptotic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Death Protein Prenylation Negative Regulation Of JAK-STAT Cascade Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Apoptotic Process Involved In Morphogenesis	Phosphatidylinositol-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Endoplasmic Reticulum Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Neurotrophin TRK Receptor Signaling Pathway T Cell Costimulation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Organic Substance Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Fc Receptor Signaling Pathway ER-nucleus Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Wound Healing Response To Unfolded Protein Response To Stress Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Component Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Response To Wounding ER-associated Ubiquitin-dependent Protein Catabolic Process Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination NFAT Protein Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of ERBB Signaling Pathway Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation
Tagcloud ?		ameliorating ces copyright drives droplet esters fibrotic flux freshly gtpase helps hsc hscs immunocytochemistry insertion isoprenylation ld lxralphabeta lxrs overload phenomena profiled res reserved retards retinoid retinyl rights stellate	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Difference) ?		ameliorating ces copyright drives droplet esters fibrotic flux freshly gtpase helps hsc hscs immunocytochemistry insertion isoprenylation ld lxralphabeta lxrs overload phenomena profiled res reserved retards retinoid retinyl rights stellate	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Intersection) ?