PPP2R1B and HYOU1

		PPP2R1B	HYOU1
Description		protein phosphatase 2 scaffold subunit Abeta	hypoxia up-regulated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol Membrane Raft Extracellular Exosome	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Spindle Assembly Meiotic Sister Chromatid Cohesion, Centromeric Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)	Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UBC UNC5B	4 interacting genes: CDC42 CEBPA LINC01554 SEL1L
Entrez ID		5519	10525
HPRD ID		04384	03448
Ensembl ID		ENSG00000137713	ENSG00000149428
Uniprot IDs		P30154	A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Circadian Regulation Of Gene Expression Protein Phosphatase Regulator Activity Cytosol Rhythmic Process Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peroxiredoxin Activity Regulation Of Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Sister Chromatid Cohesion Sister Chromatid Cohesion Cellular Response To Stress Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Removal Of Superoxide Radicals FAR/SIN/STRIPAK Complex Protein Phosphatase Activator Activity E-box Binding Positive Regulation Of Circadian Rhythm Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Schwann Cell Differentiation Response To Oxidative Stress Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Glucocorticoid Secretion Photoperiodism Regulation Of Programmed Cell Death Response To Reactive Oxygen Species Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 2A Binding Thioredoxin-dependent Peroxiredoxin Activity Nucleotide Binding Cytoplasm Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction Negative Regulation Of Neuron Apoptotic Process	Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation
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