PPP1CC and PPP1R2

Number of citations of the paper that reports this interaction (PMID 21382349)
13

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vitro)

		PPP1CC	PPP1R2
Gene Name		protein phosphatase 1, catalytic subunit, gamma isozyme	protein phosphatase 1, regulatory (inhibitor) subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667	12 interactors: CDK5 CSNK2A1 CSNK2A2 GSK3B LMTK2 NEK2 PPP1CA PPP1CC PPP1R9A PPP1R9B TERF2IP TINF2
Entrez ID		5501	5504
HPRD ID		08911	03478
Ensembl ID		ENSG00000186298	ENSG00000184203
Uniprot IDs		P36873	P41236 Q6NXS2
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter	Regulation Of Organelle Organization Cell Cycle Negative Regulation Of Chromosome Organization Rhythmic Process Regulation Of Mitotic Nuclear Division Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Cycle Process Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Neuron Development Glycogen Metabolic Process Regulation Of Cell Division Neuron Differentiation Response To External Stimulus Negative Regulation Of Telomere Maintenance Polysaccharide Metabolic Process Regulation Of Chromosome Segregation Cell Projection Organization Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Cell Growth Regulation Of Signaling Peptidyl-serine Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Axon Guidance Cellular Protein Modification Process Regulation Of Telomere Maintenance Regulation Of Mitotic Cell Cycle Energy Reserve Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Protein Metabolic Process Triglyceride Catabolic Process Generation Of Neurons Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Entrainment Of Circadian Clock By Photoperiod Neurogenesis Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Circadian Rhythm Cell Cycle Process Protein Localization To Chromosome Axonogenesis Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Export From Nucleus Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	a375 abrogating augmentation benzodiazepines calyculin contrasted dephosphorylates fmk haematological hdac6 hdaci hybridizing hybrids hypophos mechanistically melanin melanocytes offering oxamflatin phorylated pig1 prompted prospects rising saha shuffling timp vad
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	a375 abrogating augmentation benzodiazepines calyculin contrasted dephosphorylates fmk haematological hdac6 hdaci hybridizing hybrids hypophos mechanistically melanin melanocytes offering oxamflatin phorylated pig1 prompted prospects rising saha shuffling timp vad
Tagcloud (Intersection) ?