PPP1CC and TACC2

Number of citations of the paper that reports this interaction (PMID 23080069)
1

Data Source:
BioGRID (two hybrid)

		PPP1CC	TACC2
Gene Name		protein phosphatase 1, catalytic subunit, gamma isozyme	transforming, acidic coiled-coil containing protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Microtubule Cytoskeleton
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding	Protein Domain Specific Binding Nuclear Hormone Receptor Binding
	Biological Process	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	Microtubule Cytoskeleton Organization Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Astral Microtubule Organization Regulation Of Microtubule-based Process
Pathways		Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS		Heart rate ( 23583979)	Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661)
Protein-Protein Interactions		114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667	11 interactors: AURKC CREBBP EP300 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCB1 UBC YEATS4
Entrez ID		5501	10579
HPRD ID		08911	05600
Ensembl ID		ENSG00000186298	ENSG00000138162
Uniprot IDs		P36873	D6RAA5 E7EMZ9 E9PBC6 O95359 Q4VXL8
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter	Chromatin Modification N-terminal Peptidyl-lysine Acetylation Chromatin Organization Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Chromosome Organization Protein Acetylation Histone Modification Positive Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Cell Cycle Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Peptidyl-lysine Modification Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Notch Signaling Pathway Mitotic Cell Cycle RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Gene Expression Regulation Of Gene Expression Peptidyl-amino Acid Modification Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription In Response To Stress Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Process Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	abundantly affymetrix annotated ccnd1 crmp1 curing cycles ddc endpoint gabrb3 hurdle hydroxylase immunotherapy isl1 kif1a marrows mrd neuroblastoma phox2b prioritize profiling ranking sampled serves stringent surrogate top u95 uncover
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	abundantly affymetrix annotated ccnd1 crmp1 curing cycles ddc endpoint gabrb3 hurdle hydroxylase immunotherapy isl1 kif1a marrows mrd neuroblastoma phox2b prioritize profiling ranking sampled serves stringent surrogate top u95 uncover
Tagcloud (Intersection) ?