PPP1CC and NMT2

Number of citations of the paper that reports this interaction (PMID 21382349)
13

Data Source:
BioGRID (two hybrid)

		PPP1CC	NMT2
Gene Name		protein phosphatase 1, catalytic subunit, gamma isozyme	N-myristoyltransferase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding	Glycylpeptide N-tetradecanoyltransferase Activity
	Biological Process	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	Phototransduction, Visible Light Viral Process Rhodopsin Mediated Signaling Pathway N-terminal Peptidyl-glycine N-myristoylation Virion Assembly Viral Protein Processing Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Transport Of Virus
Pathways		Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins Inactivation, recovery and regulation of the phototransduction cascade HIV Life Cycle Visual phototransduction The phototransduction cascade HIV Infection Diseases associated with visual transduction Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667	12 interactors: ANXA4 ANXA7 APP BCL2 CASP3 CSNK2B PPP1CC PRKCZ SMN1 TK1 TMED9 TP53
Entrez ID		5501	9397
HPRD ID		08911	11948
Ensembl ID		ENSG00000186298
Uniprot IDs		P36873	O60551 Q5VUC6
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter	Neuron Apoptotic Process Neuron Death Release Of Cytochrome C From Mitochondria Response To Light Stimulus Response To Radiation Glial Cell Apoptotic Process Apoptotic Mitochondrial Changes Response To Organic Substance B Cell Lineage Commitment Regulation Of Protein Phosphorylation Behavior Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Protein Metabolic Process Response To Wounding Developmental Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Response To UV Membrane Organization Regulation Of Phosphorus Metabolic Process Nervous System Development Response To Oxidative Stress Cell Growth Transforming Growth Factor Beta Receptor Signaling Pathway Hemostasis Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Generation Of Neurons Cell Differentiation Negative Regulation Of Programmed Cell Death T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Cell Death Cellular Response To Glucose Starvation Neurogenesis Growth Photoperiodism Entrainment Of Circadian Clock Regulation Of Cellular Ketone Metabolic Process Response To Toxic Substance Tissue Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	125b aberrantly augmentation cadherin causal cbx7 chromobox codysregulated dcis dok4 dysregulation egr1 epithelium hn mammoplasty mcf7 memo1 microdissection mirna neoplasias nfib noncoding nrip1 paired pairs preinvasive rip140 rm underexpressed
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	125b aberrantly augmentation cadherin causal cbx7 chromobox codysregulated dcis dok4 dysregulation egr1 epithelium hn mammoplasty mcf7 memo1 microdissection mirna neoplasias nfib noncoding nrip1 paired pairs preinvasive rip140 rm underexpressed
Tagcloud (Intersection) ?