PPP1CC and NMT2

Number of citations of the paper that reports this interaction (PubMedID 21382349)
0

Data Source:
BioGRID (two hybrid)

		PPP1CC	NMT2
Description		protein phosphatase 1 catalytic subunit gamma	N-myristoyltransferase 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Host Cell
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding	Glycylpeptide N-tetradecanoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Peptidyl-lysine N6-myristoyltransferase Activity
	Biological Process	Mitotic Sister Chromatid Segregation MAPK Cascade Blastocyst Development Glycogen Metabolic Process Protein Dephosphorylation Spermatogenesis Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Rhythmic Process Cell Division Positive Regulation Of Glial Cell Proliferation	N-terminal Peptidyl-glycine N-myristoylation Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Membrane Intracellular Transport Of Virus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Membrane binding and targetting of GAG proteins eNOS activation Inactivation, recovery and regulation of the phototransduction cascade
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin	Myristoyl-Coa S-(2-oxo)pentadecylcoa 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
Diseases
GWAS		Heart rate ( 23583979)	Clozapine-induced agranulocytosis ( 25187353) Mild to moderate chronic kidney disease ( 31178898) Osteoporosis-related phenotypes (MTAG) ( 32107650) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		128 interacting genes: ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 IRAK1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R35 PPP1R3A PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SAXO4 SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VCP VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667	14 interacting genes: ANXA4 ANXA7 APP BCL2 BTF3 CASP3 CSNK2B PPP1CC PRKCZ RBM11 SMN1 TK1 TMED9 TP53
Entrez ID		5501	9397
HPRD ID		08911	11948
Ensembl ID		ENSG00000186298	ENSG00000152465
Uniprot IDs		P36873	B3KT39 O60551 Q5VUC6
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28 7SD0 8B5R	4C2X 6PAU
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Protein Phosphatase Regulator Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine/threonine Phosphatase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphatase Type 1 Complex Phosphorylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Nucleoplasm Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Inclusion Body Assembly Glycogen Binding Disordered Domain Specific Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Generation Of Precursor Metabolites And Energy Microglial Cell Activation Protein Serine Kinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphatase Binding Nucleus Glycogen Metabolic Process Leukocyte Activation Involved In Inflammatory Response Chromatin Remodeling Actin Binding Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process PML Body Type II Interferon-mediated Signaling Pathway Germ Cell Nucleus Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Energy Reserve Metabolic Process Epigenetic Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Astrocyte Activation	Response To Light Stimulus B Cell Lineage Commitment Leukocyte Apoptotic Process Glial Cell Apoptotic Process Nucleus Positive Regulation Of Neuron Apoptotic Process Response To Radiation Regulation Of Neuron Apoptotic Process Protein Tetramerization Identical Protein Binding Developmental Process Response To Metal Ion Negative Regulation Of Cell Population Proliferation Developmental Growth Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Protein Phosphatase 2A Binding Neuron Apoptotic Process T Cell Apoptotic Process B Cell Homeostasis Response To UV Release Of Cytochrome C From Mitochondria Response To Ionizing Radiation Protease Binding Response To Oxidative Stress Hematopoietic Stem Cell Differentiation Response To X-ray Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Neuron Maturation T Cell Lineage Commitment Positive Regulation Of Excitatory Postsynaptic Potential Vesicle Membrane Lymphocyte Apoptotic Process T Cell Homeostasis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cell Fate Commitment Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Regulation Of Glial Cell Proliferation Regulation Of Apoptotic Process Response To Nicotine T Cell Differentiation In Thymus Regulation Of Programmed Cell Death Cytoplasm Cellular Developmental Process Calcium-dependent Phospholipid Binding
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