PPP1CC and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 23080069)
0

Data Source:
BioGRID (two hybrid)

		PPP1CC	SHANK3
Description		protein phosphatase 1 catalytic subunit gamma	SH3 and multiple ankyrin repeat domains 3
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation MAPK Cascade Blastocyst Development Glycogen Metabolic Process Protein Dephosphorylation Spermatogenesis Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Rhythmic Process Cell Division Positive Regulation Of Glial Cell Proliferation	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Neurexins and neuroligins Neurexins and neuroligins RET signaling
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Heart rate ( 23583979)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		128 interacting genes: ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 IRAK1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R35 PPP1R3A PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SAXO4 SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VCP VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667	152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2
Entrez ID		5501	85358
HPRD ID		08911	18979
Ensembl ID		ENSG00000186298	ENSG00000251322
Uniprot IDs		P36873	Q9BYB0
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28 7SD0 8B5R	6CPK 7C7I 7C7J
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Protein Phosphatase Regulator Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine/threonine Phosphatase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphatase Type 1 Complex Phosphorylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Nucleoplasm Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Inclusion Body Assembly Glycogen Binding Disordered Domain Specific Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Generation Of Precursor Metabolites And Energy Microglial Cell Activation Protein Serine Kinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphatase Binding Nucleus Glycogen Metabolic Process Leukocyte Activation Involved In Inflammatory Response Chromatin Remodeling Actin Binding Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process PML Body Type II Interferon-mediated Signaling Pathway Germ Cell Nucleus Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Energy Reserve Metabolic Process Epigenetic Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Astrocyte Activation	Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization
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