KLF12

Description		KLF transcription factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634 32296059) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Bronchopulmonary dysplasia ( 23897914) Cervical high-risk human papilloma virus infection ( 33225922) Colorectal cancer ( 30529582) Craniofacial microsomia ( 26853712) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Energy expenditure ( 30071075) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549 28869591) Heschl's gyrus morphology ( 25130324) Lean body mass ( 28724990) Liver enzyme levels (alkaline phosphatase) ( 33972514) Long QT syndrome ( 32429735) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Menarche (age at onset) ( 25231870) Neurofibrillary tangles ( 25188341) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 25086665 26098869 20101243) Phospholipid levels (plasma) ( 22359512) Photic sneeze reflex ( 27182965) QRS duration ( 30679814 21076409 27577874 27659466 30012220) QT interval ( 24952745 29874175) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 19838195) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438) Waist-to-hip ratio adjusted for body mass index ( 27195708) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP CTBP1 DNMT3L EHMT2 FHL2 FHL3 THAP1 USP7
Entrez ID		11278
HPRD ID		06336
Ensembl ID		ENSG00000118922
Uniprot IDs		Q8WWI3 Q9Y4X4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Binding Constitutive Heterochromatin Formation Chromatin Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus P53 Binding Histone H3K56 Methyltransferase Activity Regulation Of Gene Expression Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Gene Expression Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Zinc Ion Binding Atrial Cardiac Muscle Cell Development Negative Regulation Of Autophagy
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