HLA-DRB3 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HLA-DRB3	MAP3K13
Description		major histocompatibility complex, class II, DR beta 3	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane Autolysosome Membrane	Cytoplasm Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Myeloid Dendritic Cell Antigen Processing And Presentation Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Intracellular Signal Transduction Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule	Fostamatinib
Diseases
GWAS		Plantar warts ( 28928442)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Interacting Genes		4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		3125	9175
HPRD ID		09985	05372
Ensembl ID			ENSG00000073803
Uniprot IDs		A0A4D6G1L1 P79483	O43283
PDB IDs		2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?		Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Oxytocin Production Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Positive Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Neuron Maturation IkappaB Kinase Complex Binding Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of Branching Morphogenesis Of A Nerve Chromosome Passenger Complex Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Maturation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Neuron Maturation Mitotic Spindle Midzone Assembly Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Cycle Checkpoint TRNA Threonylcarbamoyladenosine Metabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway MAP Kinase Kinase Kinase Activity Regulation Of Cell Maturation Stress-activated MAPK Cascade Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Appetite Stress-activated Protein Kinase Signaling Cascade Spindle Midzone Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation	Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Response To Cytokine Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Cytokine Production Involved In Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Regulation Of RNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction JNK Cascade MRNA Transcription Lactoylglutathione Lyase Activity Antigen Processing And Presentation Of Peptide Antigen Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Dentate Gyrus Mossy Fiber NADH-dependent Peroxiredoxin Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cytosol Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation
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