HLA-DRB3

Description		major histocompatibility complex, class II, DR beta 3
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane Autolysosome Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Myeloid Dendritic Cell Antigen Processing And Presentation Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Plantar warts ( 28928442)
Interacting Genes		4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		3125
HPRD ID		09985
Ensembl ID
Uniprot IDs		A0A4D6G1L1 P79483
PDB IDs		2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?		Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Oxytocin Production Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Positive Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Neuron Maturation IkappaB Kinase Complex Binding Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of Branching Morphogenesis Of A Nerve Chromosome Passenger Complex Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Maturation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Neuron Maturation Mitotic Spindle Midzone Assembly Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Cycle Checkpoint TRNA Threonylcarbamoyladenosine Metabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway MAP Kinase Kinase Kinase Activity Regulation Of Cell Maturation Stress-activated MAPK Cascade Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Appetite Stress-activated Protein Kinase Signaling Cascade Spindle Midzone Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation
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