HLA-DRB3 and CDCA8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HLA-DRB3	CDCA8
Gene Name		major histocompatibility complex, class II, DR beta 3	cell division cycle associated 8
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Chromosome, Centromeric Region Nucleus Nucleolus Spindle Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein Complex Intercellular Bridge
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding
	Biological Process	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Signal Transduction Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion	Mitotic Cell Cycle Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDCA8 CTAG1B MAP3K13 POMC	14 interactors: AURKB BIRC5 HIST2H3C HLA-DRB3 INCENP MAPKAPK5 NEK3 RANBP2 SGOL1 SGOL2 SUMO1 SUMO2 TTK UBE2I
Entrez ID		3125	55143
HPRD ID		09985	13017
Ensembl ID			ENSG00000134690
Uniprot IDs		P79483	Q53HL2
PDB IDs		2Q6W 3C5J 4H1L	2KDD 2QFA 2RAW 2RAX
Enriched GO Terms of Interacting Partners?			Chromosome Segregation Mitotic Cell Cycle Cell Cycle Process Protein Sumoylation Mitotic Cell Cycle Process Cell Division Cell Cycle Mitotic Nuclear Division Organelle Organization Spindle Checkpoint Mitotic Spindle Organization Peptidyl-amino Acid Modification Peptidyl-lysine Modification Cellular Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Protein Modification By Small Protein Conjugation Cytokinesis Spindle Organization Mitotic Spindle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Microtubule Cytoskeleton Organization Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Division Regulation Of Proteolysis Microtubule Anchoring Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of SUMO Transferase Activity Protein Phosphorylation Negative Regulation Of Gene Expression Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule-based Process Meiotic Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Protein Metabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Protein Catabolic Process Negative Regulation Of Binding Histone H3-S28 Phosphorylation
Tagcloud ?			allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?			allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?