FAM90A1 and EXOSC8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM90A1	EXOSC8
Gene Name		family with sequence similarity 90, member A1	exosome component 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding Zinc Ion Binding	Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: APP BANP CALCOCO2 CCDC155 CCDC57 CEP55 CEP72 CEP76 EXOSC8 FHL3 FSD2 FXR2 GABPB1 GNPTAB GOLGA2 GOPC KRT31 KRT38 KRT40 LDOC1 MID2 MTUS2 PSTPIP1 RINT1 SIAH1 SRPK2 STAC3 STX11 TMCC2 TRAF2 TRIM23 ZBTB14 ZNF212	42 interactors: AEN ATF2 COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MKRN1 MORN4 MPP6 OTUD4 RASSF1 REL RPP14 SKIV2L2 SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		55138	11340
HPRD ID		07672	09351
Ensembl ID		ENSG00000171847	ENSG00000120699
Uniprot IDs		Q86YD7	Q96B26
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Innate Immune Response Cell Cycle Immune Response Defense Response Regulation Of Protein Binding Cellular Localization Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Speck Organization Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Chromosome Localization To Nuclear Envelope Involved In Synapsis Cytoplasmic Sequestering Of CFTR Protein Organelle Organization	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Ribosome Biogenesis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process DNA Deamination Histone MRNA Catabolic Process RNA Processing Cellular Metabolic Process Histone MRNA Metabolic Process MRNA Processing Intracellular MRNA Localization Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' DNA Modification Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Splicing SnoRNA Metabolic Process RNA Splicing, Via Transesterification Reactions
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