FAM90A1 and FLOT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM90A1	FLOT1
Description		family with sequence similarity 90 member A1	flotillin 1
Image		No pdb structure
GO Annotations	Cellular Component		Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process		Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Gut microbiota (functional units) ( 27694959)	Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)
Interacting Genes		162 interacting genes: ABI2 ACTN3 AKAP9 AMOTL2 ANKRD23 ANKRD29 AP2M1 APP ARHGEF9 ARRDC3 BANP BCAR1 BEGAIN BLZF1 CADPS CALCOCO2 CARD9 CCDC13 CCDC57 CCN3 CCNC CCNL2 CDR2 CEP55 CEP70 CEP72 CEP76 CHRDL2 COG6 CYSRT1 DTX3 DVL2 DVL3 EFEMP2 ENKD1 EXOSC8 FAM228A FHL3 FLACC1 FLOT1 FOSB FSD2 FXR1 FXR2 FYN GABPB1 GCSAML GNPTAB GOLGA2 GOPC GPRASP3 GPSM1 GRIPAP1 HAND2 HMBOX1 HOMER3 HOMEZ HOOK2 HSF2BP ISY1 KANK2 KASH5 KIFC3 KLHL12 KPNA6 KRT31 KRT34 KRT38 KRT40 KRTAP1-1 KRTAP10-8 LDOC1 LHX6 LIMS1 LMO2 LNX1 LRP2BP LRRK2 LZTS1 LZTS2 MAD1L1 MDFI MEIS3 MID2 MIPOL1 MLH1 MORN3 MSS51 MTUS2 MYOG NBPF19 NDUFB7 NOTCH2NLA NUDT21 OVOL1 PBX1 PBX2 PDLIM7 PFDN5 PICK1 PIH1D1 PLAGL2 POF1B PPARA PPP1R13B PRDM6 PRKAR1B PRR23B PSME3 PSTPIP1 RAB11FIP2 RABEP1 RBM48 REL RHOH RINT1 ROPN1 RPRD1A SH2B2 SIAH1 SMAD3 SMARCB1 SNW1 SPRED1 SRPK2 STAC3 STMN2 STX11 TAX1BP1 TEPSIN TFIP11 TLE5 TMCC2 TRAF2 TRAF4 TRIB3 TRIM23 TRIM27 TRIM42 TRIM54 TRIM55 TRIM69 TRIM9 TRIML2 VRTN VWC2 ZBTB14 ZBTB16 ZBTB7B ZBTB8A ZC2HC1C ZMYND12 ZNF143 ZNF212 ZNF343 ZNF526 ZNF581 ZNF655 ZNF688 ZNF76 ZRANB1 ZWINT	26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL
Entrez ID		55138	10211
HPRD ID		07672	06105
Ensembl ID		ENSG00000171847	ENSG00000137312
Uniprot IDs		Q86YD7	O75955 Q5ST80
PDB IDs			9BQ2
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Zinc Ion Binding Cytoplasm Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Organelle Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction TORC1 Complex Assembly Cytoskeleton Signaling Adaptor Activity Protein Homodimerization Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Ubiquitination Keratin Filament Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding	Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding
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