FANCI and FANCD2

Number of citations of the paper that reports this interaction (PubMedID 17460694)
0

Data Source:
HPRD (in vitro)

		FANCI	FANCD2
Description		FA complementation group I	FA complementation group D2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane DNA Repair Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body DNA Repair Complex
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Protein Binding DNA Polymerase Binding
	Biological Process	DNA Repair DNA Damage Response Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair	DNA Repair DNA Damage Response Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		13 interacting genes: AKT1 APP ATR BRCA2 CEBPA FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1	30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7
Entrez ID		55215	2177
HPRD ID		13339	01968
Ensembl ID		ENSG00000140525	ENSG00000144554
Uniprot IDs		A0A6Q8PGF4 A0A8Q3SIW9 B3KNW8 Q9NVI1	A0A6Q8PFY3 Q9BXW9
PDB IDs		6VAA 6VAD 6VAE 6VAF 7AY1 7ZF1 8A9J 8A9K	6VAA 6VAD 6VAE 6VAF 7AY1 7KZQ 7KZR 7KZS 7KZT 7KZV 7ZF1 8A9J 8A9K
Enriched GO Terms of Interacting Partners?		Response To Radiation Interstrand Cross-link Repair DNA Repair Response To Light Stimulus Response To Gamma Radiation Nucleic Acid Metabolic Process Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Damage Response Mitotic Recombination-dependent Replication Fork Processing Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Response To Ionizing Radiation Replication Fork Processing Regulation Of Cell Cycle Response To UV Response To Stress Nuclear Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Reproductive Process Cellular Response To Ionizing Radiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Lateral Element Telomere Maintenance Via Recombination DNA Repair Complex Telomere Maintenance Nucleoplasm Regulation Of Signal Transduction Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Positive Regulation Of Proteasomal Protein Catabolic Process Mitotic Recombination Chromosome Organization Telomere Organization Positive Regulation Of Mitotic Cell Cycle Signal Transduction DNA Polymerase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process	DNA Damage Response DNA Repair DNA Metabolic Process Chromosome, Telomeric Region Chromosome Telomere Organization Cellular Response To Stress Nucleoplasm Telomere Maintenance Nucleic Acid Metabolic Process Chromosome Organization Homologous Recombination Interstrand Cross-link Repair Chromatin Remodeling Chromatin Organization Double-strand Break Repair Replication Fork Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Signal Transduction In Response To DNA Damage DNA Recombination Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint DNA Double-strand Break Processing Regulation Of Cell Cycle Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process DNA Binding Response To Stress Positive Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Regulation Of DNA Repair Post-translational Protein Modification DNA Repair Complex Regulation Of Telomere Capping Regulation Of DNA Biosynthetic Process Lateral Element
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