FANCI and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 28684355)
0

Data Source:
BioGRID (two hybrid)

		FANCI	BRCA2
Description		FA complementation group I	BRCA2 DNA repair associated
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane DNA Repair Complex	Nuclear Ubiquitin Ligase Complex Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex DNA Repair Complex
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Protease Binding DNA Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	DNA Repair DNA Damage Response Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Male Meiosis I Spermatogenesis Brain Development Cell Population Proliferation Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Chordate Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Organization Centrosome Duplication Establishment Of Protein Localization To Telomere Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Stem Cell Proliferation Cellular Senescence Mitotic Recombination-dependent Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)
Drugs
Diseases		Fanconi anemia	Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer
GWAS		Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)	Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 23535733 23535729 29059683) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		13 interacting genes: AKT1 APP ATR BRCA2 CEBPA FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1	47 interacting genes: ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		55215	675
HPRD ID		13339	02554
Ensembl ID		ENSG00000140525	ENSG00000139618
Uniprot IDs		A0A6Q8PGF4 A0A8Q3SIW9 B3KNW8 Q9NVI1	A0A7P0T9D7 A0A8V8TPZ2 P51587
PDB IDs		6VAA 6VAD 6VAE 6VAF 7AY1 7ZF1 8A9J 8A9K	1N0W 3EU7 6GY2 6HQU 7BDX 7LDG 8BR9 8C3J 8C3N 8PBC 8PBD 8QQE 8R2G 8UVW
Enriched GO Terms of Interacting Partners?		Response To Radiation Interstrand Cross-link Repair DNA Repair Response To Light Stimulus Response To Gamma Radiation Nucleic Acid Metabolic Process Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Damage Response Mitotic Recombination-dependent Replication Fork Processing Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Response To Ionizing Radiation Replication Fork Processing Regulation Of Cell Cycle Response To UV Response To Stress Nuclear Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Reproductive Process Cellular Response To Ionizing Radiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Lateral Element Telomere Maintenance Via Recombination DNA Repair Complex Telomere Maintenance Nucleoplasm Regulation Of Signal Transduction Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Positive Regulation Of Proteasomal Protein Catabolic Process Mitotic Recombination Chromosome Organization Telomere Organization Positive Regulation Of Mitotic Cell Cycle Signal Transduction DNA Polymerase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Nucleoplasm Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Response To Stress Mitotic DNA Damage Checkpoint Signaling Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Chromosome Organization Recombinational Repair Response To Ionizing Radiation Cell Cycle G2/M Phase Transition Chromosome DNA Repair Complex Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Organelle Organization Regulation Of Cell Cycle G2/M Phase Transition Interstrand Cross-link Repair Regulation Of Mitotic Cell Cycle Phase Transition Condensed Nuclear Chromosome Centrosome DNA Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Chromosome Organization Cyclin A2-CDK2 Complex Response To Radiation Damaged DNA Binding
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