TESC and SLC9A1

Number of citations of the paper that reports this interaction (PubMedID 11696366)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TESC	SLC9A1
Description		tescalcin	solute carrier family 9 member A1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex Transporter Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Phosphatase Inhibitor Activity Protein Homodimerization Activity Metal Ion Binding	Protein Binding Calmodulin Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Calcium-dependent Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Protein Transport Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Sodium:proton Antiporter Activity Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of DNA-templated Transcription Protein Stabilization Protein Maturation Cellular Response To Retinoic Acid Protein Localization To Plasma Membrane	Regulation Of The Force Of Heart Contraction Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Transmembrane Transport Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Intracellular Signal Transduction Proton Transmembrane Transport
Pathways			Hyaluronan degradation Sodium/Proton exchangers
Drugs			Amiloride Homoserine Lactone Cariporide
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Mean platelet volume ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Total hippocampal volume ( 30279459)	Lateral ventricle volume ( 31530798)
Interacting Genes		6 interacting genes: CCDC91 DYNLT3 HMG20A RAI1 SLC9A1 WBP11	12 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI TESC WNK1 YWHAB
Entrez ID		54997	6548
HPRD ID		11649	00123
Ensembl ID		ENSG00000088992	ENSG00000090020
Uniprot IDs		Q96BS2	B2RAH2 P19634
PDB IDs			1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU 6ZBI 7DSV 7DSW 7DSX
Enriched GO Terms of Interacting Partners?			Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Positive Regulation Of Sodium:proton Antiporter Activity Protein Kinase Activity Regulation Of Cellular Localization Intracellular Signaling Cassette Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Protein Kinase Inhibitor Activity Kinase Activity Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Transport Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Localization Positive Regulation Of Keratinocyte Migration Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular PH Positive Regulation Of Myotube Differentiation Regulation Of Protein Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Regulation Of PH Positive Regulation Of Cell Migration MAP Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Regulation Of RNA Metabolic Process Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Pyrimidine Nucleobase Metabolic Process Negative Regulation Of Calcium-mediated Signaling Stress-activated MAPK Cascade
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