TESC and WBP11

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TESC	WBP11
Description		tescalcin	WW domain binding protein 11
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Phosphatase Inhibitor Activity Protein Homodimerization Activity Metal Ion Binding	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Protein Transport Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Sodium:proton Antiporter Activity Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of DNA-templated Transcription Protein Stabilization Protein Maturation Cellular Response To Retinoic Acid Protein Localization To Plasma Membrane	RRNA Processing RNA Processing MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Mean platelet volume ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Total hippocampal volume ( 30279459)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CCDC91 DYNLT3 HMG20A RAI1 SLC9A1 WBP11	37 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CEBPA CTNNBL1 DDX17 DDX5 FOXP1 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PCBP4 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRMT2 PRPF40A RBM5 RSPH1 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4
Entrez ID		54997	51729
HPRD ID		11649	18293
Ensembl ID		ENSG00000088992	ENSG00000084463
Uniprot IDs		Q96BS2	Q9Y2W2
PDB IDs			7ABF 7ABG
Enriched GO Terms of Interacting Partners?			Nuclear Speck Proline-rich Region Binding Cytosol RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome PTW/PP1 Phosphatase Complex Nucleus RNA Splicing Ribonucleoprotein Complex Binding Cytoplasm Regulation Of RNA Splicing Nucleoplasm MRNA Processing Protein Domain Specific Binding Regulation Of Defense Response Protein-containing Complex Binding Regulation Of Gene Expression Scaffold Protein Binding Entrainment Of Circadian Clock By Photoperiod Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nuclear Androgen Receptor Binding Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ephrin Receptor Binding Photoperiodism Entrainment Of Circadian Clock Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process MRNA Metabolic Process Regulation Of Innate Immune Response Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Neurotrophin TRKA Receptor Binding Regulation Of MRNA Metabolic Process Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Developmental Process Regulation Of Immune System Process Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Signal Complex Assembly T Cell Costimulation
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