HPF1 and HMGA1

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (pull down)

		HPF1	HMGA1
Description		histone PARylation factor 1	high mobility group AT-hook 1
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GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Site Of DNA Damage	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Focal Adhesion Nuclear Membrane Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Structural Constituent Of Chromatin Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity Molecular Adaptor Activity Molecular Function Activator Activity
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Base-excision Repair Nucleosome Disassembly Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Oncogene-induced Cell Senescence
Pathways			Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body mass index ( 20935630 28892062 26426971) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 19343178 34054925 31562340 20881960 18391951 19396169 19893584 20189936 20397748 21998595 23563607 25282103 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 28552196 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) Weight ( 34054925)
Interacting Genes		16 interacting genes: DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	71 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 ATM CD274 CDK1 CEBPA CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EPB41L2 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B MAPK1 METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RBFOX2 RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP TP53 UPF2 WEE2-AS1
Entrez ID		54969	3159
HPRD ID		07924	02829
Ensembl ID		ENSG00000056050	ENSG00000137309
Uniprot IDs		Q9NWY4	A0A994J434 P17096 Q5T6U8
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N	2EZD 2EZE 2EZF 2EZG 8CPG
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex DNA Binding Chromatin Binding MRNA Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Binding Gland Development Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Negative Regulation Of Gene Expression Sequence-specific DNA Binding Chromatin Remodeling Nucleic Acid Binding
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