HPF1 and HMGN4

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (pull down)

		HPF1	HMGN4
Description		histone PARylation factor 1	high mobility group nucleosomal binding domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Site Of DNA Damage	Chromatin Nucleus
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Chromatin Organization
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	8 interacting genes: CEBPA EWSR1 HPF1 PARP1 SMO TERF1 TERF2 TERF2IP
Entrez ID		54969	10473
HPRD ID		07924	17111
Ensembl ID		ENSG00000056050	ENSG00000182952
Uniprot IDs		Q9NWY4	O00479
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Negative Regulation Of Telomere Maintenance Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Chromosome Organization Telomere Maintenance Protein Localization To Chromosome Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Protein Localization To Organelle Telomerase Activity Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Chromosome Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding DNA Metabolic Process DNA Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nuclear Body Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance In Response To DNA Damage Protein Poly-ADP-ribosylation Regulation Of DNA Recombination Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process
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