HPF1 and HMGN2

Number of citations: 48 (PubMedID 28190768)
Data Source: BioGRID (pull down)

		HPF1	HMGN2
Name		histone PARylation factor 1	high mobility group nucleosomal binding domain 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Site Of DNA Damage	Chromatin Extracellular Space Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity	DNA Binding Chromatin Binding RNA Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Chromatin Organization Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
GWAS		No GWAS studies recorded	Rosacea symptom severity ( 29771307 )
Interacting Genes		16 interacting genes: DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	14 interacting genes: CEBPA EP300 HMGN1 HPF1 KAT2B MTNR1A PARP1 PRKACA PRKCA RPS6KA3 SRPK2 TERF2 UBC UBE2I
Entrez ID		54969	3151
HPRD ID		07924	01230
Ensembl ID		ENSG00000056050	ENSG00000198830
Uniprot IDs		Q9NWY4	P05204
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N	Not available
GO Terms Enriched among Interactors		Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Protein Modification Process Nucleoplasm Protein Localization To Chromosome Regulation Of ATP Metabolic Process Chromatin Organization Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Chromatin Binding N-terminal Peptidyl-lysine Acetylation Response To Hormone Protein Localization To Chromatin Chromatin Remodeling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Macromolecule Metabolic Process Transferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Response To Stress Nucleus Internal Protein Amino Acid Acetylation STAT Family Protein Binding Cellular Response To Parathyroid Hormone Stimulus TOR Signaling N-terminal Protein Amino Acid Acetylation Positive Regulation Of Metabolic Process Peptidyl-lysine Acetylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Learning Or Memory Modification-dependent Protein Catabolic Process Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Hormone Protein Poly-ADP-ribosylation Carbohydrate Biosynthetic Process Cognition Protein Localization To Organelle Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Acetyltransferase Activity