HPF1 and DSCR9

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HPF1	DSCR9
Description		histone PARylation factor 1	Down syndrome critical region 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Site Of DNA Damage	Cellular_component
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity	Molecular_function
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Biological_process
Pathways
Drugs
Diseases
GWAS			Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		16 interacting genes: DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2
Entrez ID		54969	257203
HPRD ID		07924	10925
Ensembl ID		ENSG00000056050	ENSG00000230366
Uniprot IDs		Q9NWY4
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?