HPF1

Description		histone PARylation factor 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Site Of DNA Damage
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: CLCN3
Interacting Genes		16 interacting genes: DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2
Entrez ID		54969
HPRD ID		07924
Ensembl ID		ENSG00000056050
Uniprot IDs		Q9NWY4
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
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