TMEM161A and CHRM5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TMEM161A	CHRM5
Description		transmembrane protein 161A	cholinergic receptor muscarinic 5
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway
Pathways			Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs			Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		12 interacting genes: AGTR1 CCR2 CHRM5 F2RL1 GNRHR GPR35 GPR37 NR1H2 NR1H3 OXTR PTGER4 SLC22A2	31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33
Entrez ID		54929	1133
HPRD ID		07905	00331
Ensembl ID		ENSG00000064545	ENSG00000184984
Uniprot IDs		K7EPA3 Q9NX61	P08912 Q8IVW0
PDB IDs			6OL9
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Regulation Of Body Fluid Levels Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Pinocytosis Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Transport Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Regulation Of Defense Response Negative Regulation Of Cholesterol Storage Vascular Process In Circulatory System Regulation Of System Process Regulation Of Secretion By Cell Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Secretion Circulatory System Process Regulation Of Lipid Metabolic Process Regulation Of Triglyceride Biosynthetic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Dopamine Transport Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Chemokine Receptor Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Apoptotic Cell Clearance Positive Regulation Of Metabolic Process Negative Regulation Of Secretion By Cell Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Regulation Of Tube Size Plasma Membrane Positive Regulation Of Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process	Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization
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