TMEM161A and NR1H3

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TMEM161A	NR1H3
Gene Name		transmembrane protein 161A	nuclear receptor subfamily 1, group H, member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function		DNA Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis
Pathways
Drugs
Diseases
GWAS			HDL cholesterol ( 19060910 20686565) Metabolic syndrome ( 22399527)
Protein-Protein Interactions		2 interactors: NR1H2 NR1H3	30 interactors: ACTN1 APP CEP350 EDF1 EIF3I FOXO3 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA RARA RXRA RXRB RXRG SIRT1 SRC SS18L1 SUV39H1 SYT1 TMEM161A ZXDC
Entrez ID		54929	10062
HPRD ID		07905	07211
Ensembl ID		ENSG00000064545	ENSG00000025434
Uniprot IDs		Q9NX61	B4DXU5 F1D8N1 Q13133
PDB IDs			1UHL 3IPQ 3IPS 3IPU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pinocytosis Negative Regulation Of Cholesterol Storage Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Cholesterol Efflux Regulation Of Triglyceride Biosynthetic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Transport Regulation Of Triglyceride Metabolic Process Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Endocytosis Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Lipid Transport Steroid Hormone Mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Lipid Homeostasis Negative Regulation Of Immune Response Hormone-mediated Signaling Pathway Regulation Of Lipid Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly DNA-templated Transcription, Initiation Regulation Of Innate Immune Response Regulation Of Lipid Metabolic Process	Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Reproductive Structure Development Reproductive System Development Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Developmental Process Involved In Reproduction Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Retinoic Acid Receptor Signaling Pathway Reproductive Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process
Tagcloud ?			abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?			abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?