CHRM5 and NLE1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM5	NLE1
Description		cholinergic receptor muscarinic 5	notchless homolog 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	Protein Binding
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	Mitotic Cell Cycle Somitogenesis Kidney Development Inner Cell Mass Cell Differentiation Notch Signaling Pathway Regulation Of Notch Signaling Pathway Ribosomal Large Subunit Biogenesis Negative Regulation Of Mitotic Cell Cycle Skeletal System Morphogenesis Hematopoietic Stem Cell Homeostasis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	2 interacting genes: CHRM5 EWSR1
Entrez ID		1133	54475
HPRD ID		00331	16903
Ensembl ID		ENSG00000184984	ENSG00000073536
Uniprot IDs		P08912 Q8IVW0	Q9NVX2
PDB IDs		6OL9	6WAJ 8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Phosphatidylinositol Dephosphorylation Wide Pore Channel Activity Cytotoxic T Cell Pyroptotic Cell Death Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Regulation Of Dephosphorylation Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Transmission Of Nerve Impulse Dopamine Transport Pyroptotic Cell Death Acid Secretion Monoamine Transport Phosphatidylinositol-4-phosphate Binding Killing By Host Of Symbiont Cells Regulation Of Phospholipid Metabolic Process Biological Process Involved In Interaction With Symbiont Acetylcholine Receptor Signaling Pathway Pyroptotic Inflammatory Response Postsynaptic Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phosphatidylserine Binding Cajal Body
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