CHRM5 and USP33

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM5	USP33
Description		cholinergic receptor muscarinic 5	ubiquitin specific peptidase 33
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Focal Adhesion VCB Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Small GTPase Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	Proteolysis Ubiquitin-dependent Protein Catabolic Process Endocytosis Nervous System Development Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Migration Protein Deubiquitination Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Autophagosome Assembly
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	17 interacting genes: CCP110 CHRM5 DDX56 DIO2 DSCR9 EIF6 ELOC PRKN SELENBP1 SNCA TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		1133	23032
HPRD ID		00331	10297
Ensembl ID		ENSG00000184984	ENSG00000077254
Uniprot IDs		P08912 Q8IVW0	Q8TEY7
PDB IDs		6OL9	2UZG
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	Post-translational Protein Modification Dopamine Transport Monoamine Transport Protein Deubiquitination Amyloid Fibril Formation Protein Modification By Small Protein Removal Target-directed MiRNA Degradation Elongin Complex Protein Modification Process Dopamine Uptake Involved In Synaptic Transmission Protein Ubiquitination Protein Metabolic Process Selenium Binding Protein Modification By Small Protein Conjugation Catecholamine Uptake Dopamine Uptake Regulation Of ATP Metabolic Process MiRNA Catabolic Process Phenol-containing Compound Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Proteolysis Synaptic Transmission, Dopaminergic Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Neurotransmitter Reuptake Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Phospholipase Binding Regulation Of Phosphorus Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Dopamine Secretion MiRNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of MiRNA-mediated Gene Silencing Cysteine-type Peptidase Activity Deubiquitinase Activity Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Post-transcriptional Gene Silencing Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Cytosol Dopamine Metabolic Process Regulation Of Protein Stability
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