CHRM5 and SLC2A6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM5	SLC2A6
Description		cholinergic receptor muscarinic 5	solute carrier family 2 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Lysosome Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	Fructose Transmembrane Transporter Activity Protein Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	Regulation Of Glycolytic Process Hexose Transmembrane Transport Fructose Transmembrane Transport Transmembrane Transport Dehydroascorbic Acid Transport D-glucose Transmembrane Transport
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	Cellular hexose transport
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Gut microbiota (functional units) ( 27694959)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	2 interacting genes: CHRM5 TMEM14B
Entrez ID		1133	11182
HPRD ID		00331	06010
Ensembl ID		ENSG00000184984	ENSG00000160326
Uniprot IDs		P08912 Q8IVW0	Q9UGQ3
PDB IDs		6OL9
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	Acid Secretion Regulation Of Dephosphorylation Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Dopamine Transport Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Monoamine Transport Regulation Of Phospholipid Metabolic Process Heme Metabolic Process Acetylcholine Receptor Signaling Pathway Porphyrin-containing Compound Metabolic Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Postsynaptic Signal Transduction Pigment Metabolic Process Tetrapyrrole Metabolic Process Digestive System Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cerebral Cortex Development Neural Precursor Cell Proliferation
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