TMEM161A and GPR35

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TMEM161A	GPR35
Description		transmembrane protein 161A	G protein-coupled receptor 35
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		12 interacting genes: AGTR1 CCR2 CHRM5 F2RL1 GNRHR GPR35 GPR37 NR1H2 NR1H3 OXTR PTGER4 SLC22A2	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		54929	2859
HPRD ID		07905	16003
Ensembl ID		ENSG00000064545	ENSG00000178623
Uniprot IDs		K7EPA3 Q9NX61	A8K2J1 B2RA17 Q9HC97
PDB IDs			8H8J
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Regulation Of Body Fluid Levels Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Pinocytosis Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Transport Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Regulation Of Defense Response Negative Regulation Of Cholesterol Storage Vascular Process In Circulatory System Regulation Of System Process Regulation Of Secretion By Cell Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Secretion Circulatory System Process Regulation Of Lipid Metabolic Process Regulation Of Triglyceride Biosynthetic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Dopamine Transport Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Chemokine Receptor Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Apoptotic Cell Clearance Positive Regulation Of Metabolic Process Negative Regulation Of Secretion By Cell Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Regulation Of Tube Size Plasma Membrane Positive Regulation Of Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
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