CHRM5 and EPB41L1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM5	EPB41L1
Description		cholinergic receptor muscarinic 5	erythrocyte membrane protein band 4.1 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	Actin Binding Structural Molecule Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	Trafficking of AMPA receptors Neurexins and neuroligins Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Basal cell carcinoma ( 33549134) Height ( 23563607) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	20 interacting genes: AGAP2 APP ARHGAP1 CHRM5 DRD2 DRD3 GRIA1 GRIA4 HSPB1 ITPR1 NR3C1 NUMA1 POT1 SRPK2 STARD13 TERF1 USP40 YWHAB YWHAQ YWHAZ
Entrez ID		1133	2036
HPRD ID		00331	04193
Ensembl ID		ENSG00000184984	ENSG00000088367
Uniprot IDs		P08912 Q8IVW0	A0A0C4DH22 B7Z653 Q9H4G0
PDB IDs		6OL9
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	Trans-synaptic Signaling Chemical Synaptic Transmission Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Protein Domain Specific Binding Synapse Response To Morphine Regulation Of Neurotransmitter Uptake Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Associative Learning Intracellular Signaling Cassette Negative Regulation Of Protein Localization Regulation Of Protein Localization Signal Transduction Acid Secretion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Signaling Ionotropic Glutamate Receptor Signaling Pathway Cell Communication Intracellular Signal Transduction Dendrite Negative Regulation Of Synaptic Transmission Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein-containing Complex Response To Cocaine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior AMPA Glutamate Receptor Activity Synaptic Transmission, Glutamatergic Shelterin Complex Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Dendritic Spine Glutamate Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Learning Positive Regulation Of Cell Cycle Regulation Of Transport Visual Learning Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Visual Behavior
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