CHRM5 and RGS7

Number of citations: 55 (PubMedID 19182865)
Data Source: BioGRID (pull down)

		CHRM5	RGS7
Name		cholinergic receptor muscarinic 5	regulator of G protein signaling 7
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Presynaptic Membrane Neuron Projection Dendrite Terminus Postsynaptic Membrane Cell Tip Presynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil	None
GWAS		Malaria ( 31844061 )	Chronotype ( 30696823 ) Diastolic blood pressure ( 29208002 ) Longevity (90 years and older) ( 25199915 ) Major depressive disorder ( 27479909 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 ( 26634245 ) Western dietary pattern ( 28644415 )
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		1133	6000
HPRD ID		00331	03948
Ensembl ID		ENSG00000184984	ENSG00000182901
Uniprot IDs		P08912 Q8IVW0	A0A8I5KUA7 A0A8I5KXW5 A0A8I5KZ50 A0A8I5QJU0 B7Z257 P49802
PDB IDs		6OL9	2A72 2D9J 7EWP 7EWR 7SHF
GO Terms Enriched among Interactors		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Activity Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Regulation Of Protein Transport Dendrite G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Establishment Of Protein Localization GTPase Activity Regulation Of Transport Regulation Of Insulin Secretion G Protein-coupled Receptor Binding Synapse Regulation Of Peptide Hormone Secretion Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Negative Regulation Of Protein Transport Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Ciliary Basal Body Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Regulation Of Protein Localization Saliva Secretion Trans-synaptic Signaling Synaptic Signaling Regulation Of Secretion GTP Binding Negative Regulation Of Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality G Protein Activity